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Folic Acid Utilization Ability Genetic Detection CapitalBio

Folic acid is mainly involved in nucleic acid synthesis, protein synthesis, and DNA methylation in the human body, making it an essential micronutrient. The human body cannot synthesize folic acid independently and must obtain it from dietary sources. However, some individuals still develop folic acid deficiencies despite maintaining normal intake of folic acid.


folic acid utilization ability genetic detection

Features of Folic Acid Utilization Ability Genetic Detection

Features of Folic Acid Utilization Ability Genetic Detection

Consume The Same Amount Of Folic Acid, Some People Show Folic Acid Deficiency, While Some People Show Excess Folic Acid, Why?

This is mainly because genes influence the ability of each person to metabolize folic acid. In the Chinese population, genetic variations related to folic acid metabolism are as follows:

GeneSNP LociGenotype Distribution (Chinese Population)Function
MTHFRC677TCC(Normal, 28.5%); CT(Low Risk,49.8%); TT(High Risk, 21.7%)Catalyzes the production of 5-methyltetrahydrofolate, which is involved in methyl transfer and nucleotide synthesis pathways.
A1298CAA(Normal, 60.3%); AC(Low Risk,34.7%); CC(High Risk, 5%)
MTRRA66GAA(Normal, 55.9%); AG(Medium Risk, 37.7%); GG(High Risk, 6.4%)Regulates activation of  methionine synthase, a key enzyme in maintaining methyl group transfer pathways

Therefore, genetic testing to identify folic acid metabolism genotypes is recommended before personalized supplementation.

Specification of Folic Acid Utilization Ability Genetic Detection

Applicable PopulationCouples attempting to conceive, pregnant individuals
Sample TypesWhole blood / Oral cells
TAT5 working days


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